Combined effect of intermittent swimming and resveratrol consumption on antioxidant markers and lipid peroxidation index in liver tissue of older rats

Background: Aging is associated with metabolic disorders. Although the beneficial effects of exercise and resveratrol consumption in the health of the elderly has been reported, the combined effect of intermittent swimming and resveratrol consumption on the antioxidant system in liver tissue is not clear yet. Objective: This study aims to investigate the combined effect of intermittent swimming and resveratrol consumption on the expression of superoxide dismutases (SOD), glutathione peroxidase (GPx), and Malondialdehyde (MDA) in the liver tissue of older rats. Method: In this experimental study, 32 older rats were divided into four groups: control,  swimming, resveratrol and swimming+ resveratrol. The resveratrol (100 mg) dissolved in 1% methylcellulose was administrated daily by gavage. The swimming was performed at three sessions per week. The GPx and SOD expression levels were measured by real-time polymerase chain reaction method, and the MDA level was measured by ELISA method. Results: The GPx level in the swimming + resveratrol group were significantly higher than in the control (P=0.001), resveratrol (P=0.04) and swimming (P=0.002) groups. MDA levels in the resveratrol (P=0.001), swimming  (P=0.001) and swimming+resveratrol (P=0.001) groups were significantly lower than in the control group; in the swimming + resveratrol group, it was significantly lower than the resveratrol (P=0.001) and swimming (P=0.009) groups. Conclusion: It seems that intermittent swimming and resveratrol consumption have favorable effects on improving the antioxidant defense system and lipid peroxidation in liver tissue. Therefore, it is recommended to use intermittent swimming and resveratrol to prevent liver damage in the elderly.